Prodrug Activating Systems in Suicide Gene Therapy of Cancer: a Review
نویسنده
چکیده
Theoretically, prodrugs are relatively noncytotoxic molecules, capable of being converted to cytotoxic species only at the site of the tumor, affording enhanced antitumor selectivity. One approach aimed at enhancing the selectivity of cancer chemotherapy for solid tumors relies on the application of prodrug-activating systems in suicide gene therapy. Enzyme-activating prodrug therapy, also known as gene-directed enzyme prodrug therapy (GDEPT) or virus-directed enzyme prodrug therapy (VDEPT) is the form of suicide gene therapy approach where the delivered gene encodes an enzyme that activates a prodrug administered systemically causes death of own tumour cells which expresses prodrug converting enzyme. GDEPT couples cancer chemotherapy with gene therapy and offers immense therapeutic potential with more tumor specificity and less systemic toxicity. The enzyme prodrug therapy has been developed for hepatocellular carcinoma, prostate cancer, ovarian, bladder and breast cancer. The peculiarity of this approach for the treatment of cancer is reduction of dose of anti cancer agent required to produce therapeutic benefit because of its bystander effect, this is not seen with any other type of cancer treatment.
منابع مشابه
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تاریخ انتشار 2011